Google Desktop

Doesn't look like a keeper. It's taken days to fully index and is taking a boat load of disk space to do so:
drw-------   13 root  wheel       442B Apr  7 17:47 .drwxr-xr-x    3 root  wheel       102B Apr  4 07:27 ..-rw-rw--w-    1 root  wheel       329B Apr  7 12:35 Volinfo.plist-rw-r-----    1 root  wheel        40K Apr  7 16:59 indexr1_btesmam-rw-r-----    1 root  wheel        28B Apr  7 16:59 indexr1_btesmao-rw-r-----    1 root  wheel       477M Apr  7 17:22 indexr1_db-rw-r-----    1 root  wheel       160K Apr  7 17:23 indexr1_db-journal-rw-r-----    1 root  wheel       576M Apr  7 17:47 indexr1_fti-rw-r-----    1 root  wheel        10M Apr  7 17:47 indexr1_fti-journal-rw-r-----    1 root  wheel        32K Apr  7 12:35 indexr1_prop-rw-r-----    1 root  wheel       512B Apr  7 12:35 indexr1_prop-journal-rw-r-----    1 root  wheel       594M Apr  7 16:52 indexr1_repo-rw-r-----    1 root  wheel        32K Apr  7 17:23 indexr1_repo-journal

(and you have to su root to see this much info.. it's not exposed via the gui that I've seen.)